By Popoff, M. R., Revue De Medecine Veterinaire, 1991
Description
This article is an overview of the actual knowledges concerning the causative agent of foot-rot (Dichelobacter nodosus): bacteriological description, taxonomic position, virulence factors, vaccination. This bacteria shows a particular adaptation to the ruminant foot, mostly to the sheep foot. These virulence factors encompasse: pili, proteases, other lytic enzymes and undertermined membrane proteins. The pili are the main immunogens able to induce a protective immune response. However, the pili antigenic variations restrict the preparation of an universal vaccine.
This article is an overview of the actual knowledges concerning the causative agent of foot-rot (Dichelobacter nodosus): bacteriological description, taxonomic position, virulence factors, vaccination. This bacteria shows a particular adaptation to the ruminant foot, mostly to the sheep foot. These virulence factors encompasse: pili, proteases, other lytic enzymes and undertermined membrane proteins. The pili are the main immunogens able to induce a protective immune response. However, the pili antigenic variations restrict the preparation of an universal vaccine.
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