By Britt, J. S. and Carson, M. C. and Condon, R. J. and vonBredow, J. D., Journal of the American Veterinary Medical Association, 1999
Description
Objective-To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline. Design-Randomized controlled clinical trial. Animals-28 lactating Holstein cows with PDD. Procedure-Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high- performance liquid chromatography and a commercially available tetracycline screening test. Results-None of the cows in either treatment group had violative residues of oxytetracycline in milk samples. Conclusions and Clinical Relevance-Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk
Objective-To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline. Design-Randomized controlled clinical trial. Animals-28 lactating Holstein cows with PDD. Procedure-Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high- performance liquid chromatography and a commercially available tetracycline screening test. Results-None of the cows in either treatment group had violative residues of oxytetracycline in milk samples. Conclusions and Clinical Relevance-Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk
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